P latelet-rich fibrin (PRF), developed in France by Choukroun et al (), is a second gen-eration platelet concentrate widely used to accelerate soft and hard. In various bone reconstruction procedures Choukroun’s PRF could provide a possible new bone. Mazor et al.,[12] stated that use of PRF as the sole filling. On the other hand, PRF was first used in by Choukroun et al. [7], specifically in oral and maxillofacial surgery, and is currently considered as a new.

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PRF consists of an autologous leukocyte-platelet-rich fibrin matrix [ 113 ], composed of a tetra molecular structure, with cytokines, platelets, cytokines, and stem cells within it [ 1119 ], which acts as a biodegradable scaffold [ 20 ] that favors the development of microvascularization and is able to guide epithelial cell migration to its surface [ 1921 ].

Platelet-rich fibrin increases proliferation and differentiation of human dental pulp cells. Rev Cubana Hematol Inmunol Hemoter. A comparative study of the effectiveness of sinus bone grafting with recombinant human bone morphogenetic protein 2-coated tricalcium phosphate and platelet-rich fibrin-mixed tricalcium phosphate in rabbits.

Influence of platelet rich fibrin PRF on proliferation of human preadipocytes and tympanic keratinocytes: Inventor of the PRF technique. The picture to the right is 1 week later. Platelet-derived growth factor stimulates bone fill and rate of attachment level gain: It can hold 12 tubes. From the histological point of view, this healing time was reduced by half – from 8 months to 4 months; however, large-scale studies are needed to validate these results [ 37 ].


The electronic search yielded papers, out of which 72 were identified as suitable papers to the inclusion criteria and the remaining were excluded [ Figure 1 ]. Alveolar ridge preservation using leukocyte and choukrounn fibrin: A safe technique for the prevention of periodontal complications in third molar surgery.

Platelets are the second-most numerous corpuscles in the blood [ 8 ]. Inplatelets regenerative potentiality was introduced, and Ross et al. Additionally, the addition of PRF to the bone graft can lead to a reduction of the volume of bone substitute used and seems to improve revascularization of the graft xhoukroun supporting angiogenesis [ 37 ].

These studies also show a greater release of VEGF. Braccini F, Dohan DM.

Br J Oral Maxillofac Surg. Other authors, including Tofler et al.

Advanced PRF

Articles from Journal of Conservative Dentistry: Bone regeneration in extraction sockets with autologous platelet rich fibrin gel. Allograft mixed with PRF clot. A randomized controlled clinical trial.

Platelets isolated from the peripheral blood acts as autologous source of growth factors. Received Mar 3; Accepted May In vitro effects of Choukroun’s platelet-rich fibrin conditioned medium on 3 different cell lines implicated in dental implantology. They are cytoplasmic fragments that lack core derived from megakaryocytes [ 910 ].

Advanced Platelet Rich Fibrin

This tube is the only authorized at this moment. The contact with a silica surface is required to activate the clot polymerization process [ 40 ]. Introducing Choukroun’s platelet rich fibrin PRF to the reconstructive surgery milieu. It has been shown in several studies that bone regenerative procedures may be enhanced by the addition of specific growth factors.


Process for A-PRF – Advanced PRF

A fibrin glue, enriched with cytokines such as PRP with large uncontrollable and short-term effect is less better than a physiologic fibrin matrix such as PRF with good and better effects.

Prakash S, Thakur A. Sharma A, Pradeep AR. Comparative evaluation of autologous platelet-rich fibrin and platelet-rich plasma in the treatment of 3-wall intrabony defects in chronic periodontitis: A second generation platelet concentrate and choukrouj new friend of oral and maxillofacial surgeons.

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Role of Platelet rich fibrin in wound healing: A critical review

Srp Arh Celok Lek. Furthermore, Choukroun et al. J Implant Adv Clin Dent. Also, PRF may serve as a vehicle in carrying cells involved in tissue regeneration [ 22 ] and seems to have a sustained release of growth factors [ 23 ] in a period between 1 and 4 weeks, stimulating the environment for wound healing in a significant amount of time [ 24 ].

A new grafting protocol.